Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Overview
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder where an individual has lower than normal levels of the G6PD enzyme in their red blood cells. These cells are responsible for carrying oxygen from the lungs to tissues throughout the body. The G6PD enzyme plays a crucial role in maintaining the integrity of red blood cells by reducing oxidative stress caused by harmful oxygen species during normal metabolism.
Triggers and Effects
For individuals with G6PD deficiency, exposure to certain triggers—such as infections, specific drugs and substances, and the ingestion of fava beans (broad beans)—can lead to an increase in reactive oxygen species. This, in turn, causes the premature breakdown of red blood cells, known as haemolysis.
Testing and Diagnosis
Testing for G6PD deficiency is recommended in the following situations:
- When an acute haemolytic reaction occurs after exposure to a known trigger, especially in children or adults from affected ethnic groups.
- In families where jaundice and splenomegaly (enlarged spleen) are recurrent, particularly among male members.
- For newborns with severe prolonged neonatal jaundice, especially those of Mediterranean or African ancestry, as they are more likely to have G6PD deficiency.
Comprehensive Care at Mediprima Healthcare
At Mediprima Healthcare, we are dedicated to providing comprehensive and personalized healthcare services tailored to your specific needs. Our doctors will discuss the various treatment options available to ensure you receive the most appropriate care for your condition.
